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Waltham, Massachusetts, United States
Job reference: R-046707
Posted date: Mar. 12, 2019

Senior Scientist - Chemical Biology

At AstraZeneca, we work together across global boundaries to discover, develop, manufacture and market prescription medicines that make a positive impact on the lives of patients as well as their families and communities.  At AstraZeneca, our vision is redefining cancer, redefining our solutions to cancer and restoring patients' lives.  Our mission is to make a meaningful difference to patient health through great medicines that bring benefit for patients and add value for society.

In addition to our passion for the discovery of innovative new medicines, we understand the importance of flexibility in our work-life environment and we offer a wide variety of benefits, services and programs that provide our employees the resources they need to pursue not only their work goals but also their life goals.  We are dedicated to building strong research teams that embrace the diversity of talents of team members and allow the larger group to grow and learn together to accomplish our collective goal to improve human health.

Job Description:

This is an exciting opportunity to join the Chemical Biology & Proteomics team at AZ.  In this role you will contribute to the protein degradation field.  You will be responsible for quantitative mass spectrometry studies to elucidate mechanisms of action and global degradation profiles of small molecule degraders for driving key project decisions. You will have knowledge of ubiquitin proteasome biology and its role in protein homeostasis.

Key Accountabilities:

The Senior Scientist – Chemical Biology will be accountable for specified aspects of the chemical biology strategies according to the project objectives that include:

  • Designing and delivering on projects with the highest scientific standards, utilizing quantitative proteomics-based methods such as global and targeted proteomics and chemoproteomics pull-downs to address specific biological ques tions.
  • Collaborating with the chemical biology platform and project teams for experimental design and with quantitative biology for downstream pathway analysis.
  • Embedded into drug discovery project teams, demonstrating effective engagement with other disciplines (e.g. chemistry, biosciences, safety).
  • Actively contribute to shape and advancement of the scientific direction of projects as a member of cross-functional teams through presentation of their data and contribution to the overall success of the project.
  • Contribute to publication strategy as needed, driving timely preparation and delivery of patents/research publications in collaboration with IP group.
  • To evaluate and manage relations with external collaborations when and as needed.
  • Leading local discovery working groups, participate actively in global groups or global activities.
  • Ensure compliance with corporate policies including GLS and SHE. 

Essential Requirements:

Minimum: Ph.D. in Chemical Biology, Proteomics or Biochemistry with Postdoctoral experience.

Functional Knowledge:

Must be able to operate effectively in multidisciplinary matrix research environment, providing leadership and insight in their discipline. This role requires significant interactions with other scientists across the global AZ organization and with external groups.

The ideal candidate should:

  • Be familiar with chemical biology principles and technologies, and their application to understanding small molecule affects in complex biological systems.
  • Expertise in use and maintenance of Orbitrap mass spectrometers (e.g. QE+, Lumos) 
  • Expertise in proteomic sample preparation and MS quantification methods such as SILAC, TMT, iTRAQ.
  • Proficiency in data processing (Proteome Discoverer, MaxQuant) and data analysis with a fundamental knowledge of statistics.
  • The ideal candidate will have knowledge of ubiquitin proteasome biology and have previous experience with small molecule protein degraders.
  • Independently design and execute experiments for cellular signaling pathway interrogation, hypothesis testing and practical knowledge with suitable biological models and positive and negative small molecule controls.
  • Familiarity with bottom-up mass spectrometry-based applications for in cell and in vitro quantitative proteomics.
  • Preferably have an understanding of cell biology and biochemistry techniques, such as cell lysing, protein extraction and identification.
  • Be active in Chemical Biology forums and publication record in the field (communications to symposiums, peer reviewed journal articles and/or patent applications)

Areas of Expertise/Specialization

•      Awareness of recent development in literature in the field of chemical biology and/or proteomics as well as ubiquitin proteasome biology both inside and outside AstraZeneca.

•      Good communication and networking skills.

Next Steps – Apply today!

  • AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

  • To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer.  AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

Senior Scientist - Chemical Biology

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