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Waltham, Massachusetts, United States
Job reference: R-044203
Posted date: Mar. 05, 2019

Senior Scientist, Analytical Chemist, Oncology, IMED Biotech Unit

As an AnalyticalChemist (Senior Scientist) inthe Oncology group in Waltham, MA you’ll play an important role in advancing new oncology drug projects to make a positive impact on patients’ lives. This is a hands-on laboratory position within a world-leading global medicinal chemistry group with a history of delivery and innovation. At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.

We are global, innovation-driven, integrated biopharmaceutical company. Our mission is to make a meaningful difference to patient health through great medicines that bring benefit for patients and add value for society. We discover, develop, manufacture and market prescription medicines for important areas of healthcare, which include some of the world’s most serious illnesses: cancer, cardiovascular disease, respiratory, inflammation, and autoimmune diseases.  We are driven by a shared goal to make a positive impact on the lives of patients with these serious diseases. Oncology is a core therapy area and growth platform at AstraZeneca and our vision is to deliver life-changing medicines that improve outcomes for patients most in need.

In addition to our passion for the discovery of innovative new medicines, we understand the importance of flexibility in our work-life environment and we offer a wide variety of benefits, services and programs that provide our employees the resources they need to pursue not only their work goals but also their life goals.  We are dedicated to building strong research teams that embrace the diversity of talents of team members and allow the larger group to grow and learn together to accomplish our collective goal to improve human health.

Core Accountabilities:

  • Analytical chemist supporting oncology drug discovery programs through purification and analysis of potential drugs.
  • Analytical method development to solve separation problems.
  • Perform reverse phase, normal phase, and/or supercritical fluid chromatography.
  • Purification of samples in mg and gram quantities, in singleton and multiple parallel synthesis formats, based upon mass- or UV-directed collection.
  • Produce quality results in an efficient and timely manner, working individually, as well as part of a team.
  • Independently collect, analyze and interpret data, recognize aberrant results, and conduct follow-up analyses as needed.
  • Serve as analytical department representative on select synthetic/medicinal chemistry project teams, coordinating non-routine analytical requests and discussions around potential new methods needed.
  • Drive improvements to projects and department through sharing best practices.
  • Prepare summaries of work for presentations, reports, and patent applications.
  • Publish work in peer reviewed journals and/or present work at external or internal conferences.
  • Stay up-to-date with literature in analytical chemistry and advances in broader modalities that influence oncology research.
  • Able to work across functional area boundaries, for example, with colleagues in DMPK and/or computational chemistry.
  • Act in accordance with all AstraZeneca policies on personnel, safety/health/environment regulations, best laboratory practice, and Code of Conduct.

Essential Requirements:

  • BS/MS or PhD in Chemistry, Analytical Chemistry or related field, and/or several years of successful experience obtained in the pharmaceutical and/or chemical industry.
  • Demonstrated experience with chiral and achiral separations at analytical and preparative scale.
  • Experience with the operation of HPLC, UHPLC, SFC, and LC-MS instrumentation, including data interpretation.
  • Experience with troubleshooting and basic repairs of HPLC, UHPLC, and SFC instrumentation.
  • Strong written and oral communication skills are a must.
  • Strong time management skills, forward planning, and delivery focus.
  • Experience with Waters MassLynx software and Waters separation equipment is desirable (FractionLynx, Prep100, etc.)

  • Next Steps – Apply today!
  • AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

  • To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer.  AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Senior Scientist, Analytical Chemist, Oncology

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