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Location:
Waltham, Massachusetts, United States
Job reference: R-046283
Posted date: May. 31, 2019
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AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. We're proud to have a unique workplace culture that inspires innovation and collaboration. We believe in the potential of our people and you’ll develop beyond what you thought possible.

The new R&D Oncology organisation brings together early and late oncology teams, from discovery through to late-stage development, with oncology specific Regulatory and Biometrics groups.

You’ll be in a global pharmaceutical environment but also exposed to strong rigorous academic science. For example, every postdoc has an external academic mentor to ensure we are working and publishing at the highest level in a field. What’s more, you’ll have the support of a leading academic advisor, who’ll provide you with the guidance and knowledge you need to develop your career.

At AstraZeneca we believe in the potential of our people and you’ll develop beyond what you thought possible. We make the most of your skills and passion by actively supporting you to see what you can achieve. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world. If you’re curious about what science can do, then you’re our kind of person.

The Post Doc Opportunity, Accountabilities and Responsibilities:

  • Develop novel synthetic methodology in the field of photoredox catalysis.
  • Design, synthesize, and optimize ligands and novel ligand-metal photoredox complexes to   improve the efficiency of photoredox catalysts.
  • Synthesize a range of suitable heteroaryl halide species and heteroatom nucleophiles to explore the substrate scope of the catalytic process.
  • Demonstrate the utility of this methodology in the context of polyfunctional molecule synthesis by performing a total synthesis of a small natural product or pharmaceutical.
  • Work collaboratively with other internal and external experts in the field of photoredox catalysis to design and evaluate catalyst systems.
  • Show strong initiative in developing ideas and bringing them to functional use within AstraZeneca and externally.
  • Interface with scientists from across many disciplines while also being able to work independently.
  • Communicate results both by presenting to global working groups within AstraZeneca and externally at conferences.
  • Publish scientific papers in peer reviewed journals describing the discovery of novel reactions, along with substrate scope and mechanistic insights.

Education and Experience required:

Essential:

• A PhD in organic chemistry with an emphasis on synthetic methods development and/or execution of complex multi-step reaction sequences in the total synthesis of natural and non-natural products.

• Strong knowledge and working experience with common analytical techniques in a synthetic organic chemistry laboratory, including NMR, HPLC, GC and MS.

• Demonstrated ability to conduct effective independent research, develop new ideas, create solutions, and drive cross-discipline collaborations.

• Exhibit a track record of striving for a high level of innovation and scientific excellence.

• Possess excellent oral and written communication skills.

• Demonstrated success across a broad range of synthetic challenges.

• Strong working knowledge of the mechanistic principles of photoredox and transition metal chemistry and applications to synthetic problem-solving.

• Demonstrated understanding of mechanistic organic chemistry and reaction kinetics.

Desirable:

• Photoredox mediated synthetic methodology.

• High throughput or parallel chemistry approaches towards novel reaction discovery and    optimization.

• Computational approaches to transition metal ligand complexes.

This is a 3 year programme.  2 years will be a Fixed Term Contract, with a 1 year extension which will be merit based.  The role will be based in Boston, US, with a competitive salary on offer. To apply for this position, please click the apply link below.

Advert opening date – 31st May 2019 / Advert closing date – 9th August 2019

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

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Postdoc Fellow - Photoredox Methodology
Scientific

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