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Waltham, Massachusetts, United States
Job reference: R-046779
Posted date: May. 31, 2019

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. We're proud to have a unique workplace culture that inspires innovation and collaboration. We believe in the potential of our people and you’ll develop beyond what you thought possible.

The new R&D Oncology organisation brings together early and late oncology teams, from discovery through to late-stage development, with oncology specific Regulatory and Biometrics groups.

You’ll be in a global pharmaceutical environment but also exposed to strong rigorous academic science. For example, every postdoc has an external academic mentor to ensure we are working and publishing at the highest level in a field. What’s more, you’ll have the support of a leading academic advisor, who’ll provide you with the guidance and knowledge you need to develop your career.

Drug resistance is a fundamental challenge in oncology, and combination therapies represent a common strategy to avoid emergence of resistance. This role presents a unique opportunity to explore how resistance to drug combinations emerges. The results of this project will directly and immediately influence strategies for selecting and designing clinical combination regimens. You’ll have the opportunity to engage externally with top researchers in the fields of drug resistance and systems biology at leading academic research institutes.

This project will use novel genetic mutagenesis techniques combined with in vitro and patient derived models to explore the interplay between mutation status, single agent resistance and resistance to combinations.  You’ll work with a broad team of internal and external scientists and be exposed to a wide variety of preclinical oncology model systems. There will also be ample opportunity for presentation of the work internally and at external meetings, as well as for publication in high-visibility journals.

Education and Experience required;


  • PhD in a relevant discipline (e.g. biology, pharmacology, bioinformatics, bioengineering)
  • Strong lab-skills, including oncology in vitro culture and molecular biology techniques
  • Scientific leadership as evidenced by prior publication record
  • Strong analytical and quantitative capabilities
  • Candidate needs to be curious, driven, and team-player


  • Experience with patient derived tumour models
  • Experience with genome-wide screening techniques (e.g. CRISPR, mutagenesis, barcoding)
  • Experience evaluating mechanisms of oncology drug resistance

This is a 3 year programme.  2 years will be a Fixed Term Contract, with a 1 year extension which will be merit based.  The role will be based in Boston MA, with a competitive salary on offer. To apply for this position, please click the apply link below.

Advert opening date – 31st May 2019 / Advert closing date – 9th August 2019

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Postdoc Fellow - Combinations and Resistance in Oncology

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