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Waltham, Massachusetts, United States
Job reference: R-045741
Posted date: Apr. 08, 2019

Drug Discovery Senior Scientist, AstraZeneca

Become a key player in the discovery of innovative medicines

At AstraZeneca we win through science, it’s at the heart of our every success.  We continuously forge partnerships to expand our science to help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.  As a Senior Scientist, you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.

We are seeking a highly motivated and skilled PhD-level scientist with a strong background in molecular and cell biology to join the AstraZeneca Oncology Safety Sciences team at our suburban Boston, MA research center. As a Drug Discovery Senior Scientist, you will perform in vitro investigative studies to assess the role of therapeutic targets and pathways on normal tissue/cellular function, to seek a mechanistic understanding of unanticipated toxicities from projects developing novel oncology medicines and build new in vitro methods to translate findings into clinical settings.  You will work closely with a team of scientists to apply cutting edge technologies and push the boundaries of predictive safety science with our mission in mind: to discover safe innovative medicines for the patients that need them.

Essential Requirements

  • A PhD in molecular biology, pharmacology, immunology, molecular toxicology or similar discipline with at least 2 years of post-doctoral research
  • The ability to build an understanding of biology around novel targets and pathways, develop testable hypotheses, and drive scientific learning.
  • Proven experience in molecular and cellular biology techniques applied to development of physiologically-relevant cellular assays (such as tissue “organoids”) to dissect biological mechanisms (examples could include -omics technologies, gene editing, confocal imaging and/or flow cytometry and other advanced cell systems)
  • A strong publication record demonstrating scientific excellence applying molecular techniques to advance understanding of cellular biology
  • Outstanding oral presentation and written communication skills
  • Highly motivated, innovative scientist with strong influencing skills and a collaborative, team-oriented mindset

Preferred Background

  • Expertise in the design and execution of molecular biological and biochemical or cellular experiments to determine the effects of therapeutics on biological systems
  • Understanding of the drug discovery process from experience in the biotech/pharmaceutical industry

At AstraZeneca, we place a strong emphasis on individual talent development. Join us and you will be able to develop your scientific leadership by working together with leaders in cell biology, advanced imaging, ‘omic technologies, microphysiological systems, drug discovery and predictive safety science.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer.  AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country where the role is advertised.

Drug Discovery Senior Scientist

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  • Scientific, Waltham, Massachusetts, United StatesRemove