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Location:
San Francisco, California, United States
South San Francisco, California, United States
Job reference: R-055952
Posted date: Jul. 15, 2019
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At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe. As a part of our team in South San Francisco, CA you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.

Main Duties and Responsibilities

We are seeking a Scientist I,  individual contributor to join Clinical Immunology and Bioanalysis within Clinical Pharmacology and Safety Sciences organization to establish and apply a metabolomic biomarker discovery platform using mass spectrometry within the context of non-clinical and clinical studies.

Your primary responsibilities will include:

  • Establish a metabolomic discovery platform to enable discovery and validation of metabolomic/lipidomic biomarkers
  • Development, validation/qualification of state-of-the-art mass spectrometry assays in support of pharmacodynamic, mechanistic, prognostic and diagnostic analyses in variety of biological matrices
  • Sample analysis for exploratory, GLP and clinical studies using automated and manual sample extraction platforms
  • Perform data analysis on acquired datasets, collaborate with statisticians, data scientists across global AstraZeneca teams
  • Adhere to established Standard Operating Procedures, industry practice and regulatory guidance as appropriate
  • Contribute to validation/qualification protocols and reports, bioanalytical reports, clinical study reports, etc., as appropriate
  • Demonstrate competency in troubleshooting, optimization and implementation of challenging and innovative LC-MS/MS assays

Essential Requirements:

  • M.S. in Chemistry, Biochemistry or Pharmaceutical Sciences
  • 10-12 years of relevant experience

Or

  • PhD in Chemistry, Biochemistry or Pharmaceutical Sciences
  • 2-4 years of postdoctoral or equivalent experience
  • Strong background in analytical biochemistry/chemistry with emphasis on mass spectrometry applications in metabolomics, lipidomics or proteomics
  • Familiarity with high resolution and QqQ instruments; ion mobility chromatography
  • Strong publication record in metabolomics/proteomics
  • Hands-on experience with chromatographic separation of various analytes by LC, ion mobility and characterization and quantification by MS or MS/MS
  • Significant experience in method development, troubleshooting and complex omics data analysis
  • Proficiency with mass spectrometry software, data analysis software (Spotfire, MATLAB, R, JMP, etc.) word processing, and graphical computer programs
  • Good organizational, documentation and technical writing skills
  • Good command of English (written and oral)
  • Strong communication and interpersonal skills

Desirable Requirements

  • Industry experience
  • Experience with automation
  • Background in bioinformatics/statistical analysis of -omics datasets
  • Familiarity with chromatographic assay validation guidelines, GLP regulations and fit-for-purpose biomarker validation principles is beneficial
  • Familiarity with gas chromatography (GC-MS)
  • Small-molecule mass spectrometry experience
  • Familiarity with drug metabolite identification and profiling studies

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

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Scientist I - Metabolomics/Proteomics
Scientific

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