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Saffron Walden, England, United Kingdom
Job reference: R-046127
Posted date: May. 31, 2019

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. We're proud to have a unique workplace culture that inspires innovation and collaboration. We believe in the potential of our people and you’ll develop beyond what you thought possible.

The new R&D Oncology organisation brings together early and late oncology teams, from discovery through to late-stage development, with oncology specific Regulatory and Biometrics groups.

You’ll be in a global pharmaceutical environment but also exposed to strong rigorous academic science. For example, every postdoc has an external academic mentor to ensure we are working and publishing at the highest level in a field. What’s more, you’ll have the support of a leading academic advisor, who’ll provide you with the guidance and knowledge you need to develop your career.

We are the world leader in DNA-damage response (DDR) inhibitors. The project has the potential to identify new targets for drug intervention with the aim of potentiating the activity of the PARP inhibitor olaparib/Lynparza©, especially in BRCA-mutated olaparib-resistant genetic backgrounds. The project is a close collaboration with the laboratory of Dr. Violeta Serra (Vall d’Hebron Institute of Oncology, Barcelona, Spain), an expert in the molecular biology of breast cancer. Your research will take place at Chesterford Research Park in Cambridge, where the Bioscience DDR team is located, and you’ll benefit from supervision from both the academic laboratory and the AZ DDR Bioscience team. You’ll also have the opportunity to work and interact with our global DDR team and expand your skillset using various state of the art technologies.

You’ll acquire fundamentals of drug discovery and development and be exposed to the reality of patient-focused research. The breadth and depth of expertise across the AZ community with outstanding external collaborations will support you in producing high impact work that you’ll have the opportunity to publish and present to the external international scientific community.

Education and Experience required:


  • PhD in molecular and cell biology preferentially in the DNA-damage response field.
  • Oncology knowledge with an understanding of cellular signalling.
  • Proven ability to independently design and execute incisive experiments and interpret results.
  • A strong scientific track-record, as evidenced by published or accepted papers in well recognized peer-reviewed journals, oral and/or poster presentations at scientific meetings.


  • Experience in a range of in vitro biochemical, cell biology and pharmacology-related skills that can be applied to DDR and oncology research. Examples of these are growth inhibition/toxicity assays, immunoblotting, high-content biology and foci or live-cell imaging, cell cycle analysis, flow cytometry, comet and/or genotoxicity assays, CRISPR cell line models, DNA repair efficiency reporter assays.
  • Experience in working with mouse models, including xenografts.
  • Strong interpersonal, organizational and communication skills.
  • Strong passion & commitment to science, and ability to work well within a group/team environment.

Skills and Capabilities required:

  • Using a range of pre-clinical models to explore DNA damage response biology, from in vitro cell line culture to in vivo mouse xenografts.
  • Ability to work in multidisciplinary teams, as the work plan includes both in vitro cell line and in vivo mouse work.

This is a 3 year programme.  2 years will be a Fixed Term Contract, with a 1 year extension which will be merit based.  The role will be based in Cambridge, UK, with a competitive salary on offer 

To apply for this position, please click the apply link below.

Advert opening date – 31st May 2019 / Advert closing date – 9th August 2019

AZ is an equal opportunity employer. AZ will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

If you share our passion for scientific excellence, find out more at;

Postdoc Fellow - Study of olaparib resistance mechanisms

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