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Saffron Walden, England, United Kingdom
Job reference: R-041596
Posted date: Feb. 21, 2019

Director of ADME

Cambridge, UK

At AstraZeneca we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality.

Oncology DMPK has accountability for all non-clinical DMPK in AstraZeneca’s Innovative Medicine Oncology portfolio from early discovery through to launch and life cycle management.  We are looking for a senior leader who has a passion for and expertise in DMPK science, applied to Cancer biology, with the experience of working in both drug discovery and development.

The Associate Director/Director of ADME leads a team of ~10-12 individuals which collectively provide Oncology projects with experimental DMPK data, information and knowledge to build an understanding of the DMPK properties of a compound. In drug discovery this drives design strategies towards an optimal clinical candidate and prediction of clinical pharmacokinetics, efficacious and tolerable dose/schedules and drug-drug interaction profile. In drug development establishment of ADME properties enable clinical evaluation, assist dose and schedule setting, identify risks in patient populations, inform product labelling and ultimately support launching clinically meaningful drugs to patients. The Associate Director/Director of ADME has expert and broad DMPK knowledge and provides overall functional input into project teams. The individual will be an internationally recognised expert in DMPK with a strong scientific reputation and publication track record.


  • Deliver the preclinical and translational DMPK work package in projects from target validation/lead identification to launch and life cycle management.
  • Design preclinical studies and report results to Discovery project teams to evaluate and optimise series and compounds towards a selected candidate with acceptable predicted clinical PK properties and drug-drug interaction profile.
  • Provide expert technical direction, challenge and problem solving in projects.

  • Contribute to and review the non-clinical DMPK part of regulatory documents (e.g. IND, IMPD, IB, NDA)
  • Work collaboratively with other scientists including Clinical pharmacologists, bioscientists and translational scientists to ensure an adequate forward and back translation of PK, PKPD data and models.
  • Publish peer reviewed papers and reviews in internationally recognised journals.

  • Provide disciplinary scientific leadership, coaching and mentorship for less experienced scientists.

  • Identify leading improvements in science and technologies that can be successfully applied to a highly competitive drug discovery or development process that contributes to achievement of Business goals.

  • Recommend, gain commitment to, initiate, lead and champion new science and technology initiatives to improve DMPK science capability to deliver IMED projects.

  • Lead scientific discipline networks and act as a focus for debate within the AstraZeneca science community

  • Supervise student and Post Doc programmes.

  • Lead external collaborative projects with academic or cross-pharma pre-competitive groups

  • Ensure compliance with corporate code of conduct guidance, best practice SHE and AstraZeneca Good Laboratory Standards.

Qualifications, Skills and Experience Required:

  • Candidate would have a Ph. D. or equivalent in relevant scientific discipline, pharmacology, pharmaceutical sciences, with several years of relevant experience in drug discovery and development.
  • The individual should possess at least 10 years of relevant experience in DMPK with several years of experience in Oncology drug discovery and development.
  • Extensive experience of drug discovery and development projects including experience as core team member and good understanding of other disciplines
  • The person should have an international reputation within a DMPK related discipline and will be routinely publishing and presenting in external fora.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, gender or gender orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Director of ADME

AstraZeneca in the UK

Our 6,700-strong UK workforce is based across seven sites in the UK, including our new research facilities and global corporate headquarters in Cambridge. The Cambridge Biomedical Campus (CBC) is globally renowned as a leading centre of research, education and patient care. For AstraZeneca, the campus is the perfect environment in which to foster a vibrant culture of open innovation and collaboration.

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