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Location:
Macclesfield, England, United Kingdom
Job reference: R-046034
Posted date: Mar. 20, 2019
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Senior Scientist – Early Product Development

Macclesfield, UK

AstraZeneca is a global, science-driven biopharmaceutical company dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients.

Pharmaceutical Sciences is a department within AstraZeneca's R&D unit. The vision for Pharmaceutical Sciences is to deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes and manufacturing of Active Pharmaceutical Ingredients (API) and drug product. Our portfolio of projects includes traditional small molecules, nucleotide based therapies and nanomedicines across AstraZeneca’s therapy areas.

We are looking for an enthusiastic and highly capable Senior Scientist to join our Early Product Development (EPD) team in Macclesfield, UK.  As a Senior Formulation Scientist in EPD, you will be responsible for the design of drug delivery systems for clinical studies.  You will work closely with analytical, formulation, biopharmaceutics and solid-state scientists in EPD as well as scientists in other functions to drive science and innovation within drug projects. You will also collaborate with other EPD scientists at our Cambridge, Boston & Gothenburg sites.

Main Duties and Responsibilities:

  • Drive scientific product design, process and/or product performance understanding to influence strategies in early product development with line of sight to the late stage development
  • Formulate APIs into conventional, enabling and sustained release dosage forms for oral or parenteral administration
  • Support clinical manufactures and author CMC documentation for clinical applications
  • Measure physical attributes of APIs and formulated dosage forms using a variety of characterisation techniques
  • Plan and conduct lab-based experimental work in accordance with project timelines
  • Keep abreast with the scientific literature and proactively apply existing and novel approaches to projects
  • Publish novel work in peer reviewed journals

Qualifications and Experience:

  • Degree (preferably Masters or PhD) in Chemistry, Pharmaceutical Sciences or a related subject  
  • Experience of formulating and characterising a variety of dosage forms, for example, conventional immediate release tablets and capsules, amorphous solid dispersions, nanoparticles and/or lipid-based delivery systems
  • Experience in pharmaceutical science, especially formulation aspects, including demonstrating scientific leadership
  • In depth understanding of how the physicochemical and solid-state properties of the drug, dosage form and route of administration affect the rate and extent of absorption
  • Experience in building mechanistic understanding of the drug delivery system performance in vitro and linking it to in vivo performance
  • Ability to use in silico tools in compound profiling and product design

Skills and Capabilities:

  • Proven track record of problem solving and demonstrated excellent practical laboratory skills
  • Ability to handle several projects at the same time, using initiative and imagination to meet agreed objectives and timelines
  • Good team working and networking skills and an ability to engage relevant AstraZeneca staff in new initiatives
  • Ability to coach peers for enhanced individual and team performance and development
  • A good communicator with experience of interacting effectively across interfaces of discipline
  • Able to demonstrate the drive and energy to establish the role and make a difference
  • Demonstrate a high degree of personal credibility
  • Focus on delivery under pressure
  • Work collaboratively across boundaries

Applications Open 20th March 19

Applications Close 19th April 19

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, gender or gender orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

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Senior Scientist – Early Product Development
Scientific

AstraZeneca in the UK

Our 6,700-strong UK workforce is based across seven sites in the UK, including our new research facilities and global corporate headquarters in Cambridge. The Cambridge Biomedical Campus (CBC) is globally renowned as a leading centre of research, education and patient care. For AstraZeneca, the campus is the perfect environment in which to foster a vibrant culture of open innovation and collaboration.

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  • Scientific, Macclesfield, England, United KingdomRemove