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Location: Gothenburg, Västra Götaland, Sweden
Job reference: R-003912
Posted date: Mar. 10, 2017

At AstraZeneca, we believe in the potential of people who share our passion for science. By thinking boldly and working collaboratively to pursue discoveries beyond imagination, you’ll develop further and faster than you thought possible. We’ll complement your drive and determination to meet unmet patient needs around the world with the inspiration and opportunities to enhance your niche expertise and build your skills. So if you’re curious about what science can do, come and make a difference.

Our Discovery Sciences team operates from truly state-of-the-art centres spanning the UK, US and Sweden. You’ll work with some of the most knowledgeable technology experts in the industry, all collaborating on high-profile drug discovery projects. With a wide range of responsibilities, from sample management and screening to bio-reagent supply, the opportunities to develop your expertise here are limitless.

Main duties and responsibilities

Nuclear hormone receptors are ligand activated transcription factors that are critical for both development and a broad range of physiological processes.

Were looking for a talented postdoctoral scientist to join our Post Doc Programme to study the structure and function of a highly important full-length receptor in complex, state-of the art ligands and link this information to broader mode of action studies for active clinical projects. Were looking for a talented postdoctoral scientist to join our Post Doc Programme to study the structure and function of a highly important full-length receptor in complex with state-of the art ligands and link this information to broader mode of action studies for active clinical projects

You’ll gain in-depth receptor experience from extensive discovery projects and technical expertise from both AstraZeneca and the academic collaboration laboratory at CBI.

Specifically, you’ll design, express and purify a broad range of receptor constructs across several expression systems, as well as characterising ligands with different pharmacological profiles using biophysical techniques and functional assays. You’ll also determine complex structures with either X-ray crystallography or other complementary techniques such as SAXS and high-resolution cryo-EM, and explore the allosteric pathways in between the ligand binding function and different DNA response elements and co-regulator proteins. Presenting your results at scientific conferences and writing/publishing scientific papers in high-quality, peer-reviewed journals is expected.

Essential requirements

  • PhD and/or MD in biochemistry, biophysics or structural biology
  • Significant experience of protein expression methods using mammalian and insect cells
  • Strong background in construct design, molecular biology and protein purification
  • Familiarity with biophysical and structural techniques
  • Genuine understanding and experience of different assay technologies
  • Strong organisational and interpersonal skills
  • A proven record of work published in reputable scientific journals.

Desirable requirements

  • Experience of working with the following technologies: Protein Crystallization, X-ray crystallography, Small Angle X-ray Scattering, Electron Microscopy, Isothermal Titration Calorimetry and Surface Plasmon Resonance
  • Experience of expressing and purifying challenging protein complexes
  • Experience of working with DNA binding proteins.

To apply for this position, please click the apply link below

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

This is a 2-year, fixed-term contract based in Gothenburg, Sweden with a competitive salary on offer.

Opening date of advert:  15th February 2017

Closing date of advert:   18th April 2017

If you share our passion for scientific excellence, find out more at careers.astrazeneca.com

PostDoc Fellow - Functional, biophysical and structural characterisation of a multicomponent transcription factor complex
Scientific

AstraZeneca in Sweden

At AstraZeneca in Sweden we'll make the most of your skills and passion by actively supporting you. To do this, we've created a great working environment that's full of world-class talent, and opportunities for collaboration and innovation. If you're inspired by the possibilities of science to make a difference and ready to discover what you can do - join us.

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