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Gothenburg, Västra Götaland County, Sweden
Job reference: R-043469
Posted date: Jan. 30, 2019

Are you a highly experienced, knowledgable and motivated Scientist? Do you want to join a diverse and global company? We have an exciting opportunity for an Associate Principal Scientist to join the Cellular Biology Team within the Discovery Sciences department.

This position is based at our dynamic Gothenburg site. As part of the Discovery Sciences organisation, you will work in a dynamic scientific environment to push advances in small molecules and new technologies. Your main view is always to provide medicines that improve patient care.

Our Discovery Biology Department is responsible for the generation of novel and impactful reagents and assays to support projects in the drug discovery pipeline from target discovery all the way to clinical candidate. We work globally and engage with various therapeutic areas that cover cardiovascular, renal and metabolic diseases (CVRM), respiratory, as well as Infection, Neuroscience and Auto-immunity (INA).

Main Duties & Responsibilities

You will have a lab-based role with a significant component focused on developing and driving strategic scientific initiatives. Your bench-work focuses on supporting projects in all phases of drug discovery by generating bespoke cellular reagents. This includes application of leading genome engineering techniques, design of experimental strategies and troubleshooting.

Your real passion for investigating scientific questions, combined with strong team working ethics will enable you to contribute significantly to our remit.

In addition, you will be required to identify new areas relevant to the use of cellular models in drug discovery, assess their feasibility and drive their development with the goal of positively impacting projects. Key to this is the application of AI and multi-OMICS to aid in our development of relevant and translatable cellular reagents.

Essential Requirements

  • Ph. D in Cellular Biology, Pharmacology, Molecular Biology or a related degree supplemented by at least six years relevant experience, or
  • MSc degree in a relevant area supplemented by at least eight years relevant experience
  • Substantial expertise in all aspects of cellular genome engineering using a variety of techniques (with absolute requirement of the CRISPR/Cas system), from design through evolution of the tools to generate fit-for-purpose cellular reagents, as well as proven experience in downstream enrichment (FACS) and validation methods (sequencing, PCR and RT-PCR)
  • Experience in generating advanced cellular reagents and models of disease with emphasis on co-culture, 3D culture, and microphysiological systems in relevant mammalian cell types including primary and/or stem cells
  • Experience in bioinformatics, machine learning or proven working knowledge in the field of artificial intelligence applied to cellular biology
  • Documented independent capability in identifying, driving and implementing strategic initiatives and capability development within drug discovery, especially outside immediate area of expertise
  • Excellent interpersonal skills and an ability to operate effectively in a multi-disciplinary research environment

Desirable Requirements

  • Experience with microfluidics
  • Clear and firm decision-making skills coupled with tenacity to see decisions through, even in situations of ambiguity
  • Track-record in publishing scientific manuscripts in peer-reviewed journals and presenting at external conferences

If you are interested, please apply now!

For further details you are welcome to contact recruiting manager Sam Barichievy; +46 725 388 399; or

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience.

Welcome with your application no later than February 20th, 2019.

Our stunning campus in Gothenburg is one of AstraZeneca’s three strategic science centres. The site is home to over 2,500 employees, from 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide range of professionals. Our science teams in Gothenburg collaborate with academic and industry partners in Sweden and globally. And the site itself has been designed with collaboration in mind. From the Coffee Lab to exercise areas, we built a series of environments where innovation can happen.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Associate Principal Scientist – Cellular Biology

AstraZeneca in Sweden

At AstraZeneca in Sweden we'll make the most of your skills and passion by actively supporting you. To do this, we've created a great working environment that's full of world-class talent, and opportunities for collaboration and innovation. If you're inspired by the possibilities of science to make a difference and ready to discover what you can do - join us.

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