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Gaithersburg, Maryland, United States
Job reference: R-049567
Posted date: Apr. 22, 2019

At AstraZeneca, relentless pursuit is matched with exceptional capabilities to break new ground in science. We have one of the most robust pipelines in the industry, and it’s because of our people. We’re entrepreneurial and deeply collaborative – a winning combination that’s delivering life-changing medicines to patients. One of our Leadership Values is that we win through science, it’s at the heart of our every success. That science is only possible when we all work together – we’ll always make sure you’re clear about how your role is connected to our wider mission to really show what science can do.

Position Summary:

Major Duties and Responsibilities (including supervising others):

We are looking for an exceptional bioinformatics scientist with expertise in oncology research to apply state of the art genomics/genetics analytical approaches to help with understanding of disease mechanism, genetic variants, biological pathways, and predictive biomarkers with the goal of developing novel therapies and improving patient outcomes.

The candidate will mine and analyze -omics data, including DNA-based (e.g. whole exome sequencing, targeting sequencing, circulating tumor DNA), RNA-based (RNA sequencing, microarray), and other data (proteomics, etc.) along with clinical information collected as part of clinical trials and other oncology research studies. The candidate will work with scientists across research and clinical oncology to interpret findings from these analyses as they relate to oncology drug programs. The candidate must have experience working with cancer databases (e.g. TCGA, ICGC), patient clinical data, high throughput sequencing databases (e.g. GEO, SRA), and conventional NGS tools. The candidate must also be proficient programming in R. The candidate should be capable of working on multiple simultaneous projects and have experience presenting results in cross functional teams and at scientific conferences.


Education:   A M.S. or PhD in biological sciences, computational biology, bioinformatics, or relevant field.

Experience Required for a Scientist 1:

Masters - minimum 5 years experience post degree

PhD - minimum 3 years experience post degree

Special Skills/AbilitiesExperience analyzing biomarkers and developing scientific hypotheses based on disease pathogenesis and drug MOA in the areas of oncology.  A proven background interpreting biological findings from studies. Minimum of 5 years proficiency with R and at least one additional programming language required.

Job ComplexityAbility to interact in a cross-functional environment and strong oral and written skills are required.  Must have strong publication record with proven ability to lead writing of manuscripts. The candidate should be capable of multitasking and working effectively with scientists from translational oncology.

SupervisionMust have demonstrated independent work experience.

Next Steps - Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Scientist 1 - Oncology

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