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Location:
Gaithersburg, Maryland, United States
Job reference: R-032198
Posted date: Oct. 16, 2018
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If you’re inspired by the possibilities of science to change lives and you thrive when making brave decisions – join us.

MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.  Here at MedImmune, you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.

We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.

MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.

Position is a hands-on, laboratory-based role.


* The successful candidate will:


o Develop downstream processes for the manufacture of biopharmaceuticals (monoclonal antibodies and other proteins).
o Make observations, analyze data and interpret results.
o Maintain accurate records of experimental results, review, analysis, and interpretation of experimental data.
o Make periodic presentations in group meetings, project team meetings, and in one-on-one situations.
o Prepare/review development reports, tech transfer and process validation documents, regulatory submissions.
o Support technology transfer to Clinical/Commercial Manufacturing facilities.
o Support troubleshooting and resolution of deviations in GMP manufacturing processes.
o Evaluate of new technologies to facilitate process development.


R&D Associate I requires a Bachelor's Degree with 0-2 years of relevant industrial experience.

R&D Associate II requires a Bachelor's Degree with 2-5 years or a Master's Degree with 0-2 years of relevant industrial experience.

Education:
Bachelor's or Master's Degree in Biochemistry, Biochemical or Chemical Engineering, Chemistry or related field.

* Proficiency in protein purification principles and methods including (but not limited to) different modes of chromatography, viral removal/inactivation steps and filtration.


* Knowledge of:
o Basic protein chemistry; protein and analytical chemistry, process robustness concepts and process scale-up
o Working knowledge of good laboratory practices
o Purification process design
o Basic analytical techniques for protein products (HPLC analysis, protein quantification methods, electrophoresis; etc.)
o AKTA systems/software (preferred)


* Highly team-oriented, energetic, creative and critical thinker, organized, capable of significant multitasking with excellent oral and written communication skills.


* Experience considered a plus:
o Statistical design of experiments (DOE)
o Process scale-up and technology transfer
o cGMP manufacturing principles and environments
o Process validation
o Familiarity with current regulatory documentation (eg. ICH guidelines)

o Purification of protein-based therapeutics other than antibodies (eg. conjugates, bispecifics, fusion proteins or products produced by microbial systems)

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R&D Associate I / II
MedImmune

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