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Gaithersburg, Maryland, United States
Job reference: R-037025
Posted date: Nov. 12, 2018

MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.  As a Principal Scientist in Oncology Translational Medicine in Gaithersburg, MD you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.

We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.

MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.

Main Duties and Responsibilities

We are seeking a dynamic thought leader in oncology translational medicine to support Medimmune’s growing pipeline of antibody drug conjugates in our Gaithersburg, MD headquarters.  The Principal Scientist will provide exceptional scientific and strategic leadership to understand molecular heterogeneity of disease with a focus both on solid tumors and hematology/oncology and will apply this knowledge to the development of antibody drug conjugates at MedImmune. 

The Principal Scientist will work with a team of translational medicine leaders, lab-enabled scientists and bioinformatics analysts to mine genomic and proteomic data from internal and external collaborations and clinical trials. The individual will help design, execute, and analyze biomarker data from clinical studies and have a strong background in development of biologics in oncology.  An understanding of clinical trial design, regulatory processes, proof-of-concept studies, diagnostics, and biomarkers is required. The Principal Scientist will hold a leadership role on one or more Product Development Teams and in that capacity will focus on developing testable personalized healthcare strategies requiring analysis of research, translational and clinical data. The expected output is high-quality, scientifically-based product development decisions to be communicated to key stakeholders.

This is a high-profile role requiring an individual with outstanding communication and leadership skills.   Vital to this role is the ability to build strong relationships with stakeholders in Research, Clinical Development, Biostatistics and other functions within MedImmune/AstraZeneca and to work effectively with external academic collaborators. The individual must be viewed as a strong scientific and strategic leader who can work within a fast-paced organization to translate fundamental insights in the molecular heterogeneity of disease into targeted therapeutic and biomarker hypotheses that can be tested in clinical trials.  Strong project management skills and experience with IND-enabling studies and developing clinical protocols are required. The successful candidate is expected to drive the publication of manuscripts in top-tier scientific, technical or medical journals thereby establishing Medimmune’s scientific leadership.


  • The preferred candidate will have experience in the design and implementation of biomarkers in clinical studies to support development of antibody drug conjugates in oncology.
  • Experience with predictive biomarkers and precision medicine approaches is highly desired.
  • Strong collaboration skills are required that enable effective leadership within product development and scientific teams.  Must be highly effective in collaborating with external experts.
  • Must possess outstanding communication skills, both verbal and written, with the ability to deliver scientific information and proposals to audiences at all levels and functions.
  • This role requires an outstanding record of innovative contributions to translational sciences in oncology as evidenced by a strong publication record including publications in top-tier journals, inventorship on crucial patents/filings and congress presentations.
  • The successful candidate should be able to work effectively in a matrix team environment, as well as take ownership of multiple projects.
  • Organizational skills and demonstrated ability to perform quantitative analysis, graph and present data, write technical reports, and prepare biomarker protocols are required.
  • Experience developing clinical protocols and regulatory documents is highly desired.
  • The candidate will have demonstrated an ability to commit to goals and to deliver high quality results.
  • Experience mentoring and/or managing direct reports is a plus.


  • Education: PhD, MD/PhD, or MD degree in a relevant scientific field (e.g. molecular biology, immunology, cell signaling, bioinformatics).
  • A minimum of 12 years post-PhD/MD experience in an academic and/or industry setting.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Principal Scientist, R&D - Oncology Translational Medicine (Antibody Drug Conjugates)

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  • MedImmune, Gaithersburg, Maryland, United StatesRemove