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Location:
Gaithersburg, Maryland, United States
South San Francisco, California, United States
Job reference: R-024681
Posted date: Dec. 06, 2018
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If you’re inspired by the possibilities of science to change lives and you thrive when making brave decisions – join us.

MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.  As a Principal Scientist or Senior Scientist, R&D CVRM Translational Medicine in Gaithersburg, MD, you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.

We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.

MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.

Main Duties and Responsibilities

As a Principal Scientist or Senior Scientist, R&D CVRM Translational Medicine, you will be responsible for supporting TM efforts in Cardiovascular, Renal and metabolic diseases (CVRM). You will provide scientific expertise in translating preclinical data from human validation as well as animal models of CVRM diseases, including diabetes, obesity, NASH, ACS, heart failure, and chronic kidney disease (CKD) into clinically applicable tests and aid development of MedImmune’s exciting CVRM portfolio in clinical setting.  You will be expected to develop clinically testable hypotheses based on preclinical research for target engagement, pharmacodynamic response, and patient subsets that will likely benefit from the product.  As the Scientist, you will lead a matrixed team of lab-enabled scientists and bioinformatics analysts to mine genomic and proteomic data from internal and external collaborations and clinical trials to develop personalized healthcare strategies for projects.  In addition, you will develop high profile manuscripts to establish scientific leadership for MedImmune in the areas of CVRM diseases.  The principal scientist will also be expected to lead one or more Translational Science sub-teams that will support product development teams.

This is an important and visible role in product development team and requires an individual with outstanding communication and leadership skills, as well as the ability to build strong relationships with key stakeholders in Clinical, other relevant functions within MedImmune, and external academic collaborators. You must also be viewed as a strong scientific and strategic leader who can work with a fast-paced clinical and product development organization to translate fundamental insights into the molecular heterogeneity of CVRM diseases into targeted therapeutic and biomarker hypotheses that can be tested in clinical trials.   You will be expected to drive the publication of biomarker data in top-tier scientific, technical or medical journals.

Essential Requirements

  • MD, PhD/MD or PhD degree or equivalent experience in a relevant scientific field (e.g. molecular biology, cell signaling, bioinformatics).

  • For Principal Scientist: Minimum of 10-12 years post-MD/PhD relevant experience in an academic or industry setting, including significant clinical experience.
  • For Senior Scientist: Minimum of 8-10 years post-MD/PhD relevant experience in an academic or industry setting, including significant clinical experience.

Desirable Requirements

  • Outstanding record of innovative contributions to translational sciences in CVRM diseases as evidenced by a strong publication record including first / senior-authored publications in top-tier journals, inventorship on patents/filings and presentations at important conferences are a must for this role.

  • Ideally, experienced in analyzing large datasets including genomic and proteomic  together with a sound understanding of critical development functions, e.g. Clinical, Biomarker Development, Translational Medicine.

  • Firm understanding of the molecular basis of human diseases in the CVRM space with a major focus in the MD area including diabetes, obesity, NASH, and chronic kidney disease.

  • In-depth knowledge of research and clinical development of biologic therapeutics.

  • Familiarity with predictive biomarkers and personalized healthcare approaches as they pertain to research and early clinical development is highly desired.

  • Hands-on experience in development of in vitro and in vivo assays for clinical and research use, with the aim of assessing biomarkers for indication selection.

  • Understanding and ability to develop biomarker strategies and diagnostics to evaluate successful response to treatment with monoclonal antibody.

  • Familiarity with clinical protocols and regulatory processes.

  • Organizational skills with attention to detail and demonstrated ability to write technical reports, biomarker protocols, perform quantitative analyses, and graph and present data.

  • Outstanding verbal and written communication skills.

  • Strong leadership and interpersonal skills to work and lead in a matrix team environment.

  • Problem solving and organizational skills.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by lawAstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

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Principal Scientist or Senior Scientist, Translational Medicine - (Gaithersburg, MD)
MedImmune

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