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Gaithersburg, Maryland, United States
Job reference: R-040826
Posted date: Dec. 12, 2018

With one of the largest, most robust pipelines in the industry — including more than 120 research projects and product candidates — MedImmune comprises nearly half of AstraZeneca’s overall R&D portfolio. We are focused on three core therapeutic areas: Oncology; Respiratory, Inflammation and Autoimmune; and Cardiovascular and Metabolic Disease.

Given Oncology is one of the 5 key growth platforms for the company’s future success, we have an ambitious vision of delivering 6 new medicines to patients by 2020.Our strategy underpinning this vision is to target areas of unmet need, incorporate biomarker-driven patient selection, maximize value across tumor types and stages of disease, and focus on development of novel combinations.At MedImmune, our emphasis is on immuno-oncology and antibody drug conjugates (ADCs).

Position Summary:    Unique opportunity to join a newly formed tissue biomarkers and digital pathology group at Medimmune Oncology

Major Duties and Responsibilities:

MedImmune seeks an experienced MD, DVM, PhD or MD/PhD scientist with the experience in discovering/developing insights from the analysis of tumors and tissues into testable clinical hypothesis, particularly as they relate to immuno-oncology and antibody-drug conjugates.  You will have the unique opportunity to join a cross-functional team of pathologists, image analysts, bioinformaticians and translational medicine scientists. Using the latest imaging technologies and analysis tools, you will be responsible for developing an understand of the tumor contexture and how it relates to sensitivity and resistance to MedImmune’s clinical stage oncology pipeline. Your insights and analysis will help drive the long-term translational for our promising early stage programs.

Specific duties and major responsibilities include:

  • Support project teams as an internal expert on analysis of tumor tissue and its application to drug development
  • Developing strategic and effective tissue biomarker strategies for the oncology projects
  • Partnering with key stakeholders across the company to implement the translational medicine strategy
  • Implement biomarker and pathology capabilities across the oncology projects
  • Work in a cross-functional team to be at the forefront of tissue biomarker technology, including digital pathology and multi-dimensional analysis


EducationM.D., Ph.D., M.D./Ph.D., DVM/PhD, or equivalent with at least 3  years of industry or academic experience in research and development.  Training in pathology is desired.

Experience:  Demonstrated scientific credentials in analysis of tumor tissues with proven track record of translating insights into actionable drug development strategies.  Experience in techniques such as immuno-histochemistry, multiplex immuno-fluorescence, CyTOF strongly desired.  Experience and interest in developing cutting edge digital pathology approaches is preferred.  A strong candidate will have a working understanding of the development of Immuno-oncology therapeutics.

Special Skills/Abilities

  • An expert in tissue biomarkers, including digital pathology and image analysis
  • A strong understanding of the development of fit for purpose IHC assays and the analyses through all stages of drug development
  • Published in the immunology/immuno-oncology community
  • Understanding of the molecular pathways underlying cancer with demonstrated success in translating to development of drugs
  • Understanding of how digital pathology can accelerate the drug development process
  • Must have solid understanding of prognostic and predictive biomarkers and personalized healthcare approaches; understanding of bioinformatics is preferred 
  • Strong strategic thinker with the judgement and skills to influence drug-development teams
  • Outstanding verbal and written communication skills with ability to represent Medimmune Oncology translation medicine internally and externally to academic community and regulatory bodies
  • Resourceful, motivated, decisive and proactive; must be able to manage multiple priorities in a fast-paced organization
  • Organizational skills with attention to detail and demonstrated ability to review technical reports, biomarker protocols and quantitative analyses  

Job Complexity:   Complex team and program management abilities. Will be an integral member of an international cross-functional team of scientists and represent Medimmune Translational Medicine/Definiens project teams, but also could include Medimmune senior management, the academic community and regulatory bodies.   

Supervision Reports to Head of Tissue Biomarkers and Digital Pathology group in R&D.  

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

Associate Director, Tissue Biomarker

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  • MedImmune, Gaithersburg, Maryland, United StatesRemove