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Cambridge, England, United Kingdom
Job reference: R-022405
Posted date: Mar. 12, 2018

Senior Toxicologist/Immunologist

Location: Cambridge, UK

Salary: Competitive

MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease. At MedImmune our employees make up a diverse and modern workforce. Our culture is defined by a strong sense of collaboration. We believe in rewarding talent and performance, and pride ourselves on being a great place to work. 

As a Senior Toxicologist/Immunologist within the Biologics Safety Assessment (BSA) department you will be a key functional representative to Research Project and Product Development Teams focused on the development of immuno-oncology products.

This role can be filled at a Senior or Principal Scientist level.

Main duties and responsibilities:

  • Development of appropriate strategies to assess the pharmacodynamics and nonclinical safety of MedImmune assets, in particular immuno-oncology products.
  • Organising, planning and data monitoring of in vivo pharmacodynamic and toxicology studies in collaboration with Associate Scientists and Scientists.
  • Oversee the delivery of reviewed and approved final study reports, suitable for regulatory submission, in collaboration with Associate Scientists and Scientists.
  • Contribute to regulatory documents (CTAs, IMPDs, INDs, BLAs, etc); be involved in interactions with regulatory authorities as needed.
  • Communicate toxicology data internally and to Research Project and Product Development Teams, ensuring delivery in line with the business objectives of validity, integrity, quality, timing & cost.
  • Attend and/or present at relevant governance committees, including but not limited to Research Review Committees (RRC), and the MedImmune Safety Review Board (MSRB).
  • Develop investigational approaches to assess the immunomodulatory properties of MedImmune assets.
  • Act as a key functional expert in the field of immunology, pharmacology and/or nonclinical safety testing, keeping up to date with the scientific literature, attend and contribute to relevant international meetings, and publish in peer reviewed journals.

Essential Requirements

  • MSc or PhD degree in a relevant subject area – e.g. immunology, pharmacology or toxicology.
  • Experience with managing CRO-based in vivo studies.
  • Proven pharmaceutical industry experience in a relevant field (immunology, pharmacology and/or toxicology).
  • Experience with acting as a functional project representative in global project teams on early stage projects (lead optimisation-IND-Phase I).

Desirable Requirements

  • Experience with preparing and submitting regulatory documentation (CTA/IND, briefing documents) and regulatory interactions.
  •  Experience with acting as a functional project representative in global project teams on late stage projects (Phase II – BLA)

Next Steps – Apply today!

MedImmune is an equal opportunity employer. MedImmune will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Opening date: 12th March 2018

Closing Date: 2nd April 2018


Senior Toxicologist/Immunologist

AstraZeneca in the UK

Our 6,700-strong UK workforce is based across seven sites in the UK, including our new research facilities and global corporate headquarters in Cambridge. The Cambridge Biomedical Campus (CBC) is globally renowned as a leading centre of research, education and patient care. For AstraZeneca, the campus is the perfect environment in which to foster a vibrant culture of open innovation and collaboration.

Learn more

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