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Cambridge, England, United Kingdom
Job reference: R-046628
Posted date: Mar. 11, 2019

Senior Data Scientist, Oncology Bioinformatics

Cambridge, UK

At AstraZeneca when we see an opportunity for change we seize it and make it happen, because an opportunity no matter how small can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential.

The vision of AstraZeneca Oncology is to redefine cancer, redefine our solutions to cancer, and restore patients' lives.  The Oncology Bioinformatics group work within cross-disciplinary drug project teams throughout the discovery and translational pipeline, specializing in NGS and multi-omic data analysis to drive new target discovery, pre-clinical and clinical research. 

Excitingly the group is continuing to expand to harness diverse data science within our research, spanning probabilistic and mathematical modelling techniques, machine learning, artificial intelligence (AI), knowledge graphs.  We have a fantastic opportunity for a talented and motivated individual to join the team and apply their mathematical skills to drive innovation in our portfolio, working alongside resident domain expertise and the burgeoning data science community across AZ.

Main duties and responsibilities:

  • Collaborate with drug project bioscience and translational scientists to understand their scientific and technical challenges and identify where data science can best impact.
  • Collaborate with IT and quantitative science teams to devise innovative data science solutions.
  • Draw actionable insight by developing and implementing ML/AI and mathematical techniques to big data spanning clinical genomics, pre-clinical assays, and published knowledge.
  • Build models predicting new drug targets, biomarkers, and drug combination mechanisms.
  • Publish and engage the AZ and external data science communities.
  • Proactively engage in knowledge and code sharing and peer support.
  • Implement and train our bench community in FAIR data practices to augment AI.

Your skills and qualifications will ideally include:

  • Strong quantitative background with a PhD or equivalent (e.g. Master’s degree plus 2 years’ experience) in mathematics, computational statistics, physics, data science, engineering, or similar.
  • Strong applied background in one or more of Linear Algebra, Probability Theory (Bayesian, Gaussian logic etc.), and Optimization techniques.
  • Broad experience in supervised and unsupervised machine learning methods such as random forests, SVMs, penalized regression, KNN, clustering, dimensionality reduction, ensemble methods, Bayesian methods (probabilistic programming, Gaussian processes).
  • Experience in at least one of the following areas of advanced AI: deep learning, reinforcement learning, natural language processing.
  • Programming proficiency and experience with relevant software tools such as R, Python or MATLAB), version control (Git/Bitbucket), and databases (SQL as well as NoSQL).
  • Working in a Linux environment, with experience of cluster or cloud computing (e.g. AWS or Azure).
  • Excellent communication and presentation skills.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, gender or gender orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Senior Data Scientist, Oncology Bioinformatics

AstraZeneca in the UK

Our 6,700-strong UK workforce is based across seven sites in the UK, including our new research facilities and global corporate headquarters in Cambridge. The Cambridge Biomedical Campus (CBC) is globally renowned as a leading centre of research, education and patient care. For AstraZeneca, the campus is the perfect environment in which to foster a vibrant culture of open innovation and collaboration.

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