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Cambridge, England, United Kingdom
Job reference: R-027175
Posted date: Apr. 27, 2018

Position:           Computational Chemist (Fragment-Based Lead Generation)

Location:          Cambridge, UK

Salary:               Very competitive with excellent benefits

At AstraZeneca we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality.

Our scientific leadership ambition rests on our ability to attract and retain the best scientists. We continue to attract experienced scientists from academia and industry, who are excited by the quality of our science, and the potential of our pipeline that makes the Innovative Medicines and Early Development (IMED) Biotech Unit a great place to work.

At the same time, we are committed to inspiring the next generation of scientists by giving them opportunities to develop their skills and follow the science they are passionate about. 

This is an opportunity for an experienced computational chemist to play an influential role in Fragment Based medicinal chemistry projects across Innovative Medicines at AstraZeneca, based in Cambridge UK.  You will collaborate on chemistry design across multiple projects with other computational & medicinal chemists, structural biologists, biophysicists and biologists across all AstraZeneca therapeutic areas. These include Cardiovascular Renal & Metabolic disease, Oncology, Neuroscience and Respiratory & Inflammation. This will draw upon your ability to work proactively across multiple projects within a collaborative, dynamic team environment to help develop high-quality lead compounds, ultimately leading to new clinical candidate drugs.

With a strong background in modern computational medicinal chemistry techniques for small molecule optimisation, structure-based drug design and data analysis you will collaborate with others towards the success of the global fragment based lead generation group within drug discovery.

We will encourage you to share our passions for drug discovery through publishing your science in internationally recognised journals and conferences and contribute to the development of computational chemistry and medicinal chemistry disciplines. You will do this by identifying and driving improvements and innovations that advance computational capabilities to positively impact drug discovery projects.

You will have;


  • A Ph.D in the area of computational chemistry or B.Sc./M.Sc. degrees with experience of working in the area of computational chemistry.

Experience of:

  • guiding a team in the application of computational methods to drive compound design.
  • competence in structure-based and ligand-based design techniques.
  • working in a drug discovery unit or fragment chemistry group.
  • and identifying opportunities for strategic computational capability enhancements, including collaborating with external software providers and academia (as required).

Understanding of:

  • broader medicinal chemistry concepts and strategy with a track record of applying innovative solutions that have positively impacted project delivery.
  • how computational chemistry contributes to and influences drug discovery projects together with a good appreciation of other relevant disciplines, especially medicinal chemistry and structural biology. 
  • working in/across multidisciplinary project teams
  • guiding medicinal chemists on the timely application of computational methods and data analytics to influence compound design.

Apply now to join us and help turn ideas into life changing medicines!

AstraZeneca is an equal opportunity employer.  AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Senior Computational Chemist - Fragment-Based Lead Generation

AstraZeneca in the UK

Our 6,700-strong UK workforce is based across seven sites in the UK, including our new research facilities and global corporate headquarters in Cambridge. The Cambridge Biomedical Campus (CBC) is globally renowned as a leading centre of research, education and patient care. For AstraZeneca, the campus is the perfect environment in which to foster a vibrant culture of open innovation and collaboration.

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