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Location:
Cambridge, England, United Kingdom
Job reference: R-047756
Posted date: Mar. 26, 2019
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At AstraZeenca, you’ll have the opportunity to make a difference in people’s lives every single day. As one of the world’s best-in-class biopharmaceutical companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.

We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a real passion for discovery and a pipeline to show for it. We’re pioneering groundbreaking research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a rare and strong collaborative network as part of the AstraZeneca family, as together we explore alliances between small and large molecules.

AstraZeneca has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.

Within Biopharmaceutical Development (BPD), our work focuses on transforming complex molecules into medicines. This department covers the design and development of manufacturing processes and dosage forms for biopharmaceutical products - everything from molecule discovery to packaging the final product.

Within the Cell Culture Fermentation Sciences (CCFS) department, we are looking for a Scientist II to join the Upstream Bioprocess Development - Bioprocess Analytics team.

The CCFS department is responsible for delivering on and advancing AstrZeneca’s mammalian cell culture upstream process development capabilities by working as an interdisciplinary team focussed on internal technology development, external collaborations as well as a wide range of state-of-the-art drug development projects. The central theme is process optimisation.

Imagine yourself being at the forefront of technology and right at the heart of where new medicines are being discovered.

In the role of Scientist II, you are primarily responsible for rapid analytical support for process development using automated assays. You will be instrumental in supporting key decisions to be taken (cell line construction, upstream and purification process development) that are essential to progression of the portfolio biologics projects for human therapy. This is partly a lab based position where you will also be involved with the development and implementation of new process analytical technologies (PAT) for cell culture samples derived from bioreactors.

In more detail, your responsibilities will include:

  • Performance of high throughput process analytics to contribute to the development of bioprocesses for recombinant mAbs and other recombinant proteins. Techniques include liquid chromatography, capillary electrophoresis, biosensor technologies, CE-SDS, mycoplasma testing, LC-MS and Western Blot.
  • Operating automated liquid handling platforms e.g. Biomek/Hamilton/Tecan.
  • To interact with other functions in BioPharm Development and Research to develop new knowledge and new ways of working to support the product portfolio.
  • Work in a collaborative matrix environment within the BPA team supporting CCFS and Protein Purification Sciences (PPS) team. Work closely with the Analytical Sciences team as required and with the research/discovery functions.
  • To oversee students as required arising from placements or by academic collaboration.
  • Initiate or participate in academic collaborations or external technology evaluations.
  • Have a knowledge and understanding of assay practical and theoretical principles to perform process assays reproducibility and trouble shoot problems
  • Develop and implement new assays based on an understanding of critical quality attributes of recombinant protein products and their methods of production.
  • Maintain awareness of new technologies, current industrial techniques and scientific literature
  • Record all experiments accurately, clearly and in a timely fashion; prepare data summaries as required
  • Presentation of data at informal group meetings for discussion
  • Presenting at departmental meetings
  • Implement and promote AstraZeneca’s health and safety practices including the regulations governing COSHH, biological agents and genetically modified micro-organisms as detailed in the relevant risk assessments.

What we need from you:

Qualifications

  • PhD Degree in Life Sciences, Biochemical Engineering, or equivalent experience.

Knowledge/skills

  • Essential – Understanding and practical experience with analytics used to support high throughput characterisation of recombinant proteins.
  • Desirable – Knowledge of cell line development, bioreactor operation and maintenance of bioreactor processes.

Behavioural competencies

  • Hardworking, flexible and scientifically curious
  • High level of attention to detail
  • The ability to work collaboratively in a team

If you are passionate about drug development and you want to develop your career in one of the world leading biotech companies, apply now!

To be considered for this exciting opportunity, we ask you to please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a good fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, gender or gender orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

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Scientist II - BioProcess Analytics
MedImmune

AstraZeneca in the UK

Our 6,700-strong UK workforce is based across seven sites in the UK, including our new research facilities and global corporate headquarters in Cambridge. The Cambridge Biomedical Campus (CBC) is globally renowned as a leading centre of research, education and patient care. For AstraZeneca, the campus is the perfect environment in which to foster a vibrant culture of open innovation and collaboration.

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