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Location: Cambridge, England, United Kingdom Gothenburg, Västra Götaland, Sweden
Job reference: R-003871
Posted date: Mar. 24, 2017

At AstraZeneca, we believe in the potential of people who share our passion for science. By thinking boldly and working collaboratively to pursue discoveries beyond imagination, you’ll develop further and faster than you thought possible. We’ll complement your drive and determination to meet unmet patient needs around the world with the inspiration and opportunities to enhance your niche expertise and build your skills. So if you’re curious about what science can do, come and make a difference.

Cancer is one of the greatest challenges facing medical science today. In our Oncology Team, you’ll push the boundaries of science every day to overcome that challenge. We’ve been at the centre of some of the biggest breakthroughs in oncology. In lung cancer, for example, we‘ve brought together complementary expertise to aid discovery and accelerate development in new medicines through a variety of partnerships and initiatives. We’re also early adopters of new technologies to support innovation, including CRISPR, genome editing techniques and a next-generation sequencing platform for companion diagnostics in oncology. But we’re not stopping there. With a world-class pipeline and some of the best experts in the industry, we’re in a great position to develop even more innovative therapeutic approaches.

Main duties and responsibilities

Keen to broaden your skills in synthetic organic chemistry, as well as high-throughput and medicinal chemistry, in a creative drug discovery scientific environment?  This is a unique opportunity to strengthen one’s organic chemistry skills at the interface between small molecules synthesis and medicinal chemistry, in both an industrial and a world-leading academic setting.

Your first year will be spent in the University of Cambridge, being guided and mentored by Professor Matthew Gaunt and Medicinal Chemists at AstraZeneca Cambridge UK. The remainder of your time will be spent within the Medicinal Chemistry department of the Oncology Disease Area. You’ll be working within the Excellence in Synthesis/Automation team – a vibrant, multinational group focused on integrating chemical technology and automation to challenging strategic medicinal chemistry. You’ll also work with the Cardiovascular and Metabolic Disease Area. There will be some opportunity to spend a short amount of time with this group in Gothenburg.

Key tasks will be to develop C-H functionalisation protocols for use in late stage functionalisation, as well as reaction plates for the transformations to be used in a semi-automated platform. You’ll also apply these platforms in a medicinal chemistry setting to functionalise drug-like molecules.Working collaboratively with scientists from across multiple disciplines, you’ll communicate your results both within AstraZeneca via global working groups and externally at scientific meetings and through high impact publications. 

Essential requirements

  • PhD in synthetic organic chemistry and/or medicinal chemistry
  • Excellent skills in classical organic chemistry, purification and structural elucidation technique
  • In-depth knowledge and understanding of late stage functionalisation reactions such as C-H functionalisation and catalyst chemistry
  • Interest in high-throughput chemistry
  • Strong organisational and interpersonal skills
  • An outstanding track record of research, proven by high-impact publications in peer-reviewed journals, patents and/or talks at scientific meetings
  • Ability to independently design and execute experiments, and interpret results
  • Ability to work towards defined goals in an efficient, safe and scientifically sound manner
  • Experience of generating and testing new hypothesis
  • Willingness to share expertise and ideas, flexibility and open-mindedness
  • Track record of presenting results at scientific conferences and publishing scientific papers in high-quality, peer-reviewed journals.

Desirable requirements

  • Expertise in late stage functionalisation reactions techniques
  • Knowledge and hands-on experience of high-throughput synthesis
  • Previous postdoc experience
  • Ability to work in multidisciplinary teams, high levels of collaboration and communication within team and across department.


To apply for this position, please click the apply link below

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

This is a 2 year Fixed Term Contract opportunity, plus 1 year which will be merit based.  The role will be based at Cambridge, UK  and Gothenburg, Sweden with a competitive salary on offer  

Opening date of advert:  17th February 2017

Closing date of advert:   2nd May 2017

If you share our passion for scientific excellence, find out more at careers.astrazeneca.com

PostDoc Fellow - High throughput platform for Late Stage Functionalization
Scientific

AstraZeneca in the UK

Our 6,700-strong UK workforce is based across seven sites in the UK, including our new research facilities and global corporate headquarters in Cambridge. The Cambridge Biomedical Campus (CBC) is globally renowned as a leading centre of research, education and patient care. For AstraZeneca, the campus is the perfect environment in which to foster a vibrant culture of open innovation and collaboration.

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