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Location: Cambridge, England, United Kingdom Gothenburg, Västra Götaland, Sweden
Job reference: R-003717
Posted date: Apr. 10, 2017

Associate Director –DMPK New Modalities

Location: Cambridge, UK or Gothenburg, Sweden

Salary: Competitive + excellent benefits

At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.

As an Associate Director - DMPK within the New Modalities group you will play a pivotal role in developing DSM nucleotide DMPK/ADME discovery and regulatory strategies. As a DMPK leader, with experience in the fields of biologics, antisense oligonucleotides and/or modRNA you will focus on establishing and developing our preclinical DMPK capabilities in this exciting and rapidly moving area. To do this you will need to collaborate across the IMED Biotech unit to apply your science to the fundamental platform enabling questions that we face today. 

The New Modalities group is a newly created group within our Drug Safety and Metabolism (DSM) function. Our vision for the New Modalities group is to deliver the therapies of the future through scientific leadership in preclinical safety and disposition evaluation of nucleotide platforms and associated advanced delivery systems across our therapeutic functions.

If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us.

Main duties and responsibilities:

As an Associate Director- DMPK within the New Modalities group you will be develop, lead and champion our Drug Safety and Metabolism nucleotide DMPK/ADME discovery and regulatory strategies. You will identify opportunities to develop existing and emerging technologies for application to nucleotide DMPK to better understand the disposition and kinetics for delivery systems and nucleotide modalities. By collaborating with colleagues from Modelling and Simulation group you develop and apply advanced physiological based PK (PBPK) modelling approaches to inform human disposition. You will also contribute to Regulatory Development strategies and input into IMPD/IND documentation.

Managing New Modalities in vitro colleague(s) to determine appropriate application of existing and emerging technologies will be an important part of your role.  You will interact with senior and junior staff from all disciplines and areas, e.g. DMPK scientists, PKPD modelers, toxicologists, and project teams to provide an integrated understanding of disposition and DMPK of nucleotide modalities. You will apply DMPK principles to input into, and develop, in vitro and in vivo translational mitigation strategies to quantify and contextualize human safety assessment and human DMPK predictions in a patient centric manner.

As an Associate Director - DMPK within the New Modalities group you will be involved in Identify and manage opportunities for high value collaborations with academic or industrial institutions. You will be driving innovation and enhance AstraZeneca’s scientific reputation by publishing high caliber research and engaging in external collaborations.

Essential requirements:

  • Degree or equivalent (Masters or PhD preferred) in a DMPK related discipline with significant experience of working in industrial environment (Pharma, CRO or biotech)
  • Recognised leader with proven track record of publications in DMPK/ADME or PKPD fields
  • Experience in the field of biologics DMPK
  • Demonstrated ability to apply innovative scientific approaches to address problems in a translational manner
  • Demonstrated ability to work in multi-disciplinary teams and manage in matrix environment Highly effective communication skills: presentations, manuscript preparation, influencing and relationship building

Desired requirements:

  • Experience in building and applying PBPK models
  • Experience in DMPK of antisense oligonucleotides, siRNA or modified RNA therapeutics
  • Proven experience in preclinical regulatory documentation preparation and submission
  • Prior experience of application of DMPK & PKPD principles to drug safety and quantitative risk assessment
  • Knowledge of, and applied experience in, advanced delivery formulation systems such as lipid nanoparticles and exosomes and impact on DMPK/ADME strategies

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

Closing date: 10th May 2017

Associate Director – DMPK New Modalities

AstraZeneca in the UK

Our 6,700-strong UK workforce is based across seven sites in the UK, including our new research facilities and global corporate headquarters in Cambridge. The Cambridge Biomedical Campus (CBC) is globally renowned as a leading centre of research, education and patient care. For AstraZeneca, the campus is the perfect environment in which to foster a vibrant culture of open innovation and collaboration.

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